KIR3DL3-HHLA2 interactions defend tumors
HHLA2 (a B7 member of the family) has each immune inhibitory and activating talents and is expressed in lots of human cancers. These differing features depend on the receptor to which it binds, but many of those receptors are uncharacterized. Right here, Wei et al. discovered that KIR3DL3 sure to HHLA2 and was expressed on effector reminiscence CD8+ T cells and CD56dim NK cells. Interactions of KIR3DL3 with tumoral HHLA2 inhibited the operate and killing capability of each CD8+ T cells and NK cells. KIR3DL3+ immune cells infiltrated numerous sorts of HHLA2+ tumors from sufferers with most cancers, and blockade of KIR3DL3 inhibited the expansion of tumors in numerous mouse fashions. Thus, KIR3DL3-HHLA2 inhibits immune-mediated clearance of tumor cells and presents a potential immunotherapeutic goal for most cancers.
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